€513.00 €436.05
Amyloid plaques composed primarily of the 42 amino acid form of amyloid-? peptide (A?42) are a hallmark of Alzheimer’s disease (AD). However, the roles of the various amyloid ? peptide(s), especially A?42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating the role of A? in AD pathology has been the availability of anti-A? antibodies to selectively detect A? versus amyloid precursor protein (APP), A?40 versus A?42, and specific conformations of the peptide, particularly oligomeric forms. MOAB-2 (mouse IgG2b) is a pan-specific antibody specific to A? (residues 1-4) that differentiates intracellular A? from APP. MOAB-2 does not detect APP in cell culture media/lysates or in brain homogenates from transgenic mice expressing 5 familial AD mutation (5xFAD mice). Intraneuronal A? was confirmed by co-localization of MOAB-2 immunoreactivity with C-terminal antibodies specific for A?40 and A?42, and with cathepsin-D, a lysosomal marker. Additionally, MOAB-2 demonstrates strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.{20683}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 200 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | Oligomeric form of amyloid-? peptide (A?42) |
| Clone | 6C3 |
| Isotype | IgG2b |
| Application(s) | ELISA, ICC, IP, WB |
| Formulation | 200 µg of protein G-purified antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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