Amyloid-? (17-42) Peptide (human) (trifluoro<wbr/>acetate salt)

Amyloid-? (17-42) Peptide (human) (trifluoroacetate salt)

CAT N°: 27415
Price:

€365.00 €310.25

Amyloid-? (A?) (17-42) is a 26-residue fragment of the A? protein that is formed via post-translational processing of amyloid precursor protein (APP) by ?- and ?-secretases.{47355} It has been found in postmortem cerebral cortex from patients with Alzheimer’s disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down’s syndrome.{47356,47357} In vitro, A? (17-42) forms amorphous aggregates that bind less thioflavin T than A? (1-40) (Item No. 21617) and A? (1-42) (Item No. 20574).{47357} It is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells when used at a concentration of 20 ?M.{47355}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-?-glutamyl-L-?-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine, trifluoroacetate salt
  • Correlated keywords
    • 155178-13-5 H-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH Amyloid? ? posttranslational post-mortem SHSY5Y SY 5Y IMR32 ADPribose PA RP A?1742
  • Product Overview:
    Amyloid-? (A?) (17-42) is a 26-residue fragment of the A? protein that is formed via post-translational processing of amyloid precursor protein (APP) by ?- and ?-secretases.{47355} It has been found in postmortem cerebral cortex from patients with Alzheimer’s disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down’s syndrome.{47356,47357} In vitro, A? (17-42) forms amorphous aggregates that bind less thioflavin T than A? (1-40) (Item No. 21617) and A? (1-42) (Item No. 20574).{47357} It is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells when used at a concentration of 20 ?M.{47355}

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