24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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€439.00 €373.15
Amylin is a 37-residue peptide hormone secreted by pancreatic ?-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety.{35231,38842,38841,38840} It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3 (IC50s = 7.86 and 6.35 nM, respectively).{39432} It also binds to mouse ?-thyroid-stimulating hormone thyrotroph (?-TSH) cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM).{38840,39432} In vitro, amylin (100 nM) inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats.{38841} It also inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats.{38840} In vivo, amylin delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 ?g/kg).{38842,38840} Unlike human amylin (Item No. 24274), rat amylin does not form fibrils and is not cytotoxic.{38843}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C167H272N52O53S2 • XCF3COOH |
| Smiles | NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H]3CCCN3C(CNC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](N4)CSSC[C@H](NC([C@H](CCCCN)N[H])=O)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C4=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O.FC(F)(C(O)=O)F |
| Molecular weight | 3920,4 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom code | 3504.00 |
| UNSPSC code | 12352100 |
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