Amoxapine

Amoxapine

CAT N°: 17347
Price:

From 48.00 40.80

Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM.{22877} It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), ?1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.{25805,25914}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepine
  • Correlated keywords
    • neuroscience tetracyclic antidepressant inhibitor norepinephrine serotonin transporter reuptake antagonist inverse agonist 5-HT dopamine ?1-adrenergic histamine receptor biochemical inhibit biochemistry anti-depressant 5-HT2A 5-HT2B 5-HT2C 5-HT3 5-HT6 5-HT7 5-HT-2A 5-HT-2B 5-HT-2C 5-HT-3 5-HT-6 5-HT-7 5HT2A 5HT2B 5HT2C 5HT3 5HT6 5HT7 D2 D3 D4 D-2 D-3 D-4 H1 Amoxan Asendin Asendis Demolox Moxadil 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
  • Product Overview:
    Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM.{22877} It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), ?1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.{25805,25914}

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