Amonafide

Amonafide

CAT N°: 31623
Price:

From 75.00 63.75

Amonafide is a DNA-intercalating topoisomerase II poison.{59203} It reduces the formation of kinetoplast DNA minicircles, a marker of topoisomerase II activity, in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA, a marker of topoisomerase I activity, at the same concentration.{59204} Amonafide inhibits growth in a panel of 11 human cancer cell lines, including leukemia, gastric, breast, and lung cancer cells, with GI50 values ranging from 1 to 10 µM.{59205} It induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, when used at concentrations ranging from 2.5 to 10 µM. Amonafide (5 mg/kg) reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model.{59206}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
  • Correlated keywords
    • Huh 7 H 22 NSC308847 AS 1413 benzo isoquinoline dione NCI308847
  • Product Overview:
    Amonafide is a DNA-intercalating topoisomerase II poison.{59203} It reduces the formation of kinetoplast DNA minicircles, a marker of topoisomerase II activity, in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA, a marker of topoisomerase I activity, at the same concentration.{59204} Amonafide inhibits growth in a panel of 11 human cancer cell lines, including leukemia, gastric, breast, and lung cancer cells, with GI50 values ranging from 1 to 10 µM.{59205} It induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, when used at concentrations ranging from 2.5 to 10 µM. Amonafide (5 mg/kg) reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model.{59206}

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