Amiodarone (hydro<wbr>chloride)

Amiodarone (hydrochloride)

CAT N°: 15213
Price:

From 48.00 40.80

Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-?-hydroxysteroid ?8?7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors ? and ? (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride
  • Correlated keywords
    • 1951-25-3 inhibitors cardiology vascular diseases channels blockers ions antiarrhythmic agents anti-arrhythmic anti arrhythmic potassium currents blocks blockage hERG voltage-gated voltages gated KCNH2 amiodar HCl aminodaronum ancoron angiodarona atlansil cordarex cordarone X cordarone-X Ls 3428 L3428 L-3428 3428 labaz miocard miodaron ortacrone pacerone ritmocardyl rythmarone SKFs 33134A SKF33134A SKF-33134A trangorex cardiac actions potentials sigma-1 opioid receptors 3-?-hydroxysteroid ?8?7 isomerase 3-.beta.-hydroxysteroid .DELTA. 8 7 DELTA 3-beta-hydroxysteroid C-8 sterol isomerase thyroid hormones .alpha. .beta. ? ? cytochrome P450 CYPs CYP2C8 CYP3A4
  • Product Overview:
    Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-?-hydroxysteroid ?8?7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors ? and ? (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}

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