Amiloride (hydro<wbr>chloride) (hydrate)

Amiloride (hydrochloride) (hydrate)

CAT N°: 14409
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Amiloride is a potassium-sparing diuretic.{22817,22815} It is an inhibitor of the epithelial sodium channel (ENaC; K0.5 = 2.6 µM for recombinant ?ENaC expressed in X. laevis oocytes).{54348} It inhibits sodium transport from bovine kidney cortex membrane vesicles with an IC50 value of 0.4 µM.{48507} Amiloride inhibits the urokinase-type plasminogen activator (u-PA; Ki = 7 µM) and cardiac Na+/H+-ATPase (IC50 = 83.8 µM).{54349,54350} It also inhibits calcium currents mediated by transient receptor potential polycystin 3 (TRPP3; IC50 = 143 µM).{24798} Amiloride (30 mg/kg) reduces mean arterial pressure in spontaneously hypertensive, but not normotensive, rats.{54351} Formulations containing amiloride have been used alone, and in combination with thiazide diuretics, in the treatment of hypertension.

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