Amifostine thiol (hydrochloride)

Amifostine thiol (hydrochloride)

CAT N°: 18612
Price:

68.00 57.80

Amifostine thiol is a radioprotective agent and an active metabolite of amifostine (Item No. 14398).{52402} It is formed from amifostine by plasma membrane-bound alkaline phosphatase. Amifostine thiol scavenges ABTS (Item No. 27317) radicals in a cell-free assay.{47394} It prevents single- and double-stranded DNA breaks induced by ?-radiation, as well as inhibits ?-radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in V79-B310H lung fibroblast cells when used at a concentration of 4 mM.{52403,52404,52405} Amifostine thiol also reduces cis-DDP-induced mutations at the HGPRT locus in V79-B310H cells.{52406} It increases survival, reduces the loss of bone marrow progenitor cells, and inhibits decreases in intestinal collagen thickness and crypt and Paneth cell density in mice exposed to total body ?-irradiation when administered at a dose of 500 mg/kg prior to irradiation.{52407}

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