AMG 333

AMG 333

CAT N°: 36825
Price:

From 46.00 39.10

AMG 333 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 13 and 20 for the human and rat channels, respectively).{69085} It is selective for TRPM8 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, and TRP ankyrin 1 (TRPA1; IC50s = >20, >20, >20, and >40 µM, respectively), as well as a panel of 100 kinases and 144 additional targets at 1 and 10 µM, respectively. AMG 333 (0.6-3 mg/kg) decreases wet-dog shakes, a behavioral marker of cold sensation, induced by the TRPM8 agonist icilin (Item No. 10137) in rats.

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