Amcasertib

Amcasertib

CAT N°: 22980
Price:

From 129.00 109.65

Amcasertib is an inhibitor of cancer stem cells (CSCs).{41289} It inhibits the growth of HT-29 and MDA-MB-231 cancer cells (IC50s = 100-250 nM for both) and exhibits a 2-fold increase in potency for a population of SW480 cells enriched for CSCs. Amcasertib reduces spherogenesis of CD44+-enriched FaDu cells. Oral administration of amcasertib (100 mg/kg) reduces tumor growth in PC3, HepG2, FaDu, and MKN45 mouse xenograft models. Amcasertib also inhibits EGFR, C-MET, HER2, and PDGFR? in vitro without reducing global tyrosine kinase activity.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-(diethylamino)ethyl]-5-[[1,2-dihydro-2-oxo-5-(2-phenyl-4-thiazolyl)-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • Correlated keywords
    • BB503 BBI-503 Nanog CMET HER-2 MKN 45 SW 480 Hep G2 HT29 MDAMB231
  • Product Overview:
    Amcasertib is an inhibitor of cancer stem cells (CSCs).{41289} It inhibits the growth of HT-29 and MDA-MB-231 cancer cells (IC50s = 100-250 nM for both) and exhibits a 2-fold increase in potency for a population of SW480 cells enriched for CSCs. Amcasertib reduces spherogenesis of CD44+-enriched FaDu cells. Oral administration of amcasertib (100 mg/kg) reduces tumor growth in PC3, HepG2, FaDu, and MKN45 mouse xenograft models. Amcasertib also inhibits EGFR, C-MET, HER2, and PDGFR? in vitro without reducing global tyrosine kinase activity.

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