Alternariol mono<wbr/>methyl ether

Alternariol monomethyl ether

CAT N°: 11307
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Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 ?g/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 ?M in HCT116 cells).{38070,38071} It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 ?M, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 ?M).{33238,38072} AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.{38071}

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