Alrestatin

Alrestatin

CAT N°: 29888
Price:

From 129.00 109.65

Alrestatin is an inhibitor of aldose reductase (IC50 = 1.5 µM for rat lens enzyme).{52459} It is selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC50 = 58 µM). Alrestatin reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations.{52458} In vivo, alrestatin (0.75 mmol/kg) increases plasma insulin levels in fasted anesthetized rats. Alrestatin inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes.{52460} It also inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED50s = 90 and 330 mg/kg, respectively).

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