24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.{39317,39318,39319,39320} It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 ?M, respectively) at concentrations well below the cytotoxic concentration (CC50) of >86.5 ?M in vitro.{39317} Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC50 values of 40, 270, and 360 ?M, respectively.{39318} Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension.{39319} Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-?, IL-1?, and IL-6 in a mouse model of allergic contact dermatitis.{39320}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 500 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 56293-29-9 |
| Molecular formula | C15H24N2 |
| Smiles | [H][C@]12CCCCN1C[C@@]3([H])C[C@]2([H])C=C4[C@@]3([H])NCCC4 |
| Molecular weight | 232,4 |
| Custom code | 2921.30 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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