Aloperine

Aloperine

CAT N°: 22259
Price:

97.00 82.45

Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.{39317,39318,39319,39320} It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 ?M, respectively) at concentrations well below the cytotoxic concentration (CC50) of >86.5 ?M in vitro.{39317} Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC50 values of 40, 270, and 360 ?M, respectively.{39318} Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension.{39319} Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-?, IL-1?, and IL-6 in a mouse model of allergic contact dermatitis.{39320}

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