Alobresib

Alobresib

CAT N°: 30726
Price:

From 85.00 72.25

Alobresib is an inhibitor of bromodomain and extra-terminal domain (BET) proteins.{59886,59887} It inhibits proliferation of MEC-1 chronic lymphocytic leukemia cells (CLL; IC50 = 46.4 nM).{59886} Alobresib (400 nM) decreases the levels of Blk and Myc and increases the levels of I?B? in patient-derived CLL cells co-cultured with nurse-like cells (NLC). It inhibits proliferation of USPC-ARK-1 and USPC-ARK-2 uterine serous carcinoma (USC) cells with IC50 values of 31 and 27 nM, respectively.{59887} Alobresib (10 and 20 mg/kg, p.o.) reduces tumor growth in a USPC-ARK-2 USC mouse xenograft model.

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