Allo<wbr/>pregnanolone

Allopregnanolone

CAT N°: 16930

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone (Item No. 15876).{27521} It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing ? subunits) and of GABAC receptors at µM concentrations.{27521} Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.{27521,26687}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Please check regulation status before ordering; additionel fees can apply.

  • Synonyms
    • 3?-hydroxy-5?-pregnan-20-one
  • Correlated keywords
    • GABAA receptor neurosteroid positive allosteric modulator pregnane anticonvulsant anxiolytic sedative neuroscience epilepsy mood disorders biochemical biochemistry steroidal allotetrahydroprogesterone 3?5?pregnanolone 3?,5?-pregnanolone tetrahydroprogesterone modulator inhibitor inhibitory inhibit progesterone GABAC potentiator anticonvulsant anxiolytic sedative
  • Product Overview:
    Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone (Item No. 15876).{27521} It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing ? subunits) and of GABAC receptors at µM concentrations.{27521} Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.{27521,26687}

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