all-<em>trans</em> Retinoic Acid

all-trans Retinoic Acid

CAT N°: 11017
Price:

From 54.00 45.90

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RAR?, RAR?, and RAR?, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RAR?, RAR?, or RAR? (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of ?-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
  • Correlated keywords
    • 7005-78-9 56573-65-0 187175-63-9 NSC122758 AGN 100335 AGN100335 COS7 Tretinoin
  • Product Overview:
    all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RAR?, RAR?, and RAR?, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RAR?, RAR?, or RAR? (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of ?-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}

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