Alendronate (sodium hydrate)

Alendronate (sodium hydrate)

CAT N°: 13642
Price:

From 42.00 35.70

Alendronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 50 nM for the recombinant human enzyme).{41320} It inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM).{18288} Alendronate (3 and 10 µM) reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts.{41902} It prevents femoral bone mineral density loss in ovariectomized rats when administered at a dose of 5 mg/kg.{17616} Formulations containing alendronate have been used in the treatment of osteoporosis and Paget’s disease.

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