24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 ?M, respectively).{34359} This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.{34330} Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.{34359,34360} Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 ?M, respectively).{34359}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 147084-10-4 |
| Molecular formula | C19H21N3O |
| Smiles | O=CC1=CN=C2N1CCC(C=CC=C3)=C3/C2=C4CCN(C)CC4, O=CC1=CN=C2N1CCC(C=CC=C3)=C3/C2=C4CCN(C)CC4, O=CC1=CN=C2N1CCC(C=CC=C3)=C3/C2=C4CCN(C)CC4, O=CC1=CN=C2N1CCC(C=CC=C3)=C3/C2=C4CCN(C)CC4 |
| Molecular weight | 307,4 |
| Custom code | 2933.39 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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