Ajmalicine

Ajmalicine

CAT N°: 31213
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Ajmalicine is an terpenoid indole alkaloid that has been found in R. serpentina.{21130,46769} It is an ?1-adrenergic receptor antagonist, reducing the phenylephrine-induced pressor response in pithed rats when administered at doses ranging from 1 to 4 mg/kg.{61048} It also binds to ?2A-, ?2B-, ?2C-, and ?2D-adrenergic receptors (Kis = 8.2, 14.5, 5, and 289 nM, respectively).{34495} Ajmalicine, in combination with almitrine, improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs.{61049}

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