AG957

AG957

CAT N°: 17259
Price:

From 55.00 46.75

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.{15153} AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins).{29184} It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM).{29184} As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line.{29187,29186} AG957 is also used to study signaling through c-Abl.{29185}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester
  • Correlated keywords
    • biochemical inhibitor kinase protein cancer signal transduction intracellular signaling receptor biochemistry AG-957 NSC654705 Bcr-Abl c-Abl BcrAbl cAbl
  • Product Overview:
    Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.{15153} AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins).{29184} It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM).{29184} As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line.{29187,29186} AG957 is also used to study signaling through c-Abl.{29185}

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