AG-636

AG-636

CAT N°: 36122
Price:

From 83.00 70.55

AG-636 is a dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 17 nM).{68068} It increases levels of ureidosuccinic acid (Item No. 34126) and DHO, pyrimidine biosynthesis metabolites upstream of DHODH, in a panel of six cell lines when used at a concentration of 1 µM. AG-636 (100 mg/kg) induces complete tumor stasis in an OCI-Ly19 diffuse large B cell lymphoma (DLBCL) mouse xenograft model and complete tumor regression in a Z-138 ibrutinib-resistant mantle cell lymphoma mouse xenograft model. It also increases DHO levels and reduces pyrimidine levels in Z-138 and JeKo-1 lymphoma mouse xenograft models.

We also advise you