AG-<wbr/>126

AG-126

CAT N°: 13297
Price:

From 48.00 40.80

Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 ?M.{17267,17268} It blocks the production of TNF-? in vitro{17268} and in vivo,{17267} attenuating signaling through NF-?B,{17267} the induced expression of COX-2 and iNOS,{17269,17266} and the inflammatory response in diverse animal models.{17269,17270} AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 ?M){14963} and platelet-derived GFRK (IC50 > 100 ?M).{14964}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile
  • Correlated keywords
    • tyrphostins proteins tyrosine inhibitors inhibits inhibition cells growth epidermal growth factors receptors kinase GFRK EGFs EGFRK PDGF PDGFRK platelet-derived platelet derived phosphorylation ERK1 p44 ERK2 p42 TNF-? TNF? TNF ? NF-?B NF?B NF ?B COX-2 COX2 iNOS inflammation
  • Product Overview:
    Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 ?M.{17267,17268} It blocks the production of TNF-? in vitro{17268} and in vivo,{17267} attenuating signaling through NF-?B,{17267} the induced expression of COX-2 and iNOS,{17269,17266} and the inflammatory response in diverse animal models.{17269,17270} AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 ?M){14963} and platelet-derived GFRK (IC50 > 100 ?M).{14964}

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