AF38469

AF38469

CAT N°: 35530
Price:

100.00 85.00

AF38469 is an inhibitor of sortilin, also known as the neurotensin-3 receptor (NTS3; IC50 = 330 nM).{66001} It is selective for sortilin over neurotensin-1 (NTS1), ?-opioid, angiotensin II type 1 (AT1), endothelin A (ETA), and ETB receptors, GPR40, PPAR?, and matrix metalloproteinase-12 (MMP-12), and the prostaglandin E2 (PGE2) receptor subtype EP1. AF38469 (400 nM) inhibits the epithelial-to-mesenchymal transition (EMT) in, and reduces migration and invasion of, U87 and A172 glioblastoma cells.{66002} It also reduces tumor growth in a glioblastoma multiforme mouse xenograft model when administered at a dose of 0.01 g/kg per day.

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