ACY-775

ACY-775

CAT N°: 29198
Price:

From 48.00 40.80

ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases ?-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.

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