Actinonin

Actinonin

CAT N°: 16605
Price:

From €169.00 €143.65

Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).{27523}} Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.{27463} Actinonin has also been identified as an effective inhibitor of human meprin ? (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.{24095} More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.{27522}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2R)-N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide
  • Correlated keywords
    • aminopeptidase metalloproteinase PDF meprin ? antitumor anticancer apoptosis mitochondria MMP-1 MMP1 MMP2 MMP3 MMP7 MMP8 MMP9 MMP10 MMP12 MMP13 N-terminal endopeptidase actinonine CONA 57 CON
  • Product Overview:
    Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).{27523}} Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.{27463} Actinonin has also been identified as an effective inhibitor of human meprin ? (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.{24095} More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.{27522}

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