€604.00 €513.40
Acetylcholinesterase (AChE) is a homotetrameric carboxylesterase that is composed of four 70 kDa subunits with each subunit containing a single active site.{42309} It is a product of alternative splicing and can be membrane bound via a glycosyl-phosphatidylinositol anchor in the membrane or a proline-rich membrane anchor (PRIMA) peptide linker for erythrocyte and synaptic AChE, respectively, or soluble in water, with each form demonstrating identical catalytic activity.{42310} AChE is primarily found in red blood cells as well as at neuromuscular junctions and in the brain at cholinergic synapses where it hydrolyzes acetylcholine to acetate and choline to terminate synaptic transmission.{42310,42311} It accelerates amyloid-? (A?) fibrillogenesis in vitro and overexpression of AChE accelerates A? plaque formation and disease progression in the Tg2576 transgenic mouse model of Alzheimer’s disease.{42312} AChE activity is also increased in islets of Langerhans in rats with diabetes induced by streptozotocin (Item No. 13104). Cayman’s AChE (eel) Monoclonal Antibody (clone 5E2) can be used for Western blot and ELISA applications. This antibody recognizes AChE at ~72 kDa from electric eel samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | Purified native AChE electric eel protein |
| Clone | 500 |
| Isotype | IgG2b |
| Application(s) | ELISA, WB |
| Formulation | 500 µg of protein G-purified IgG |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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