Acetyl<wbr/>digitoxin

Acetyldigitoxin

CAT N°: 24024
Price:

From 237.00 201.45

Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes.{41362} This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force.{29469,38192} Formulations containing acetyldigitoxin have been used for the treatment of heart failure and chronic atrial fibrillation.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3?,5?)-3-[(O-3-O-acetyl-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?-D-ribo-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide
  • Correlated keywords
    • sodium potassium acetyl monoacetyl Acylanid Adicin Desglucolanatoside Monoacetyldigitoxin digitoxin digoxin ?-
  • Product Overview:
    Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes.{41362} This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force.{29469,38192} Formulations containing acetyldigitoxin have been used for the treatment of heart failure and chronic atrial fibrillation.

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