Ac-DMQD-CHO (trifluoro<wbr/>acetate salt)

Ac-DMQD-CHO (trifluoroacetate salt)

CAT N°: 27103
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From 140.00 119.00

Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM).{42637} It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin (Item No. 11694) in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord.{42638}

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