Ac-DEVD-<em>p</em>NA

Ac-DEVD-pNA

CAT N°: 14460
Price:

From 48.00 40.80

During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.{22861} Ac-DEVD-pNA is a para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 µM for caspases-1, -3, -4, -6, and -7, respectively).{7213} It is not cleaved by caspase-2.{7213} Cleavage is monitored colorimetrically at 405 nm.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-acetyl-L-?-aspartyl-L-?-glutamyl-L-valyl-N-(4-nitrophenyl)-L-?-asparagine
  • Correlated keywords
    • 189950-66-1 apoptosis enzymes substrates cells deaths dyes indicators CPP32 CPP-32 CPP 32 caspase-3 caspases 3 1 4 6 7 caspase-1 caspase-1 caspase-4 caspase-6 caspase-7 cleavages ADP-ribose adenosines diphosphates ADP riboses poly polymerases PARP DEVD aminos acids sequences chromophores AcDEVD pNAs para para-nitro anilines colorimetric stubstrates
  • Product Overview:
    During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.{22861} Ac-DEVD-pNA is a para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 µM for caspases-1, -3, -4, -6, and -7, respectively).{7213} It is not cleaved by caspase-2.{7213} Cleavage is monitored colorimetrically at 405 nm.

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