Ac-DEVD-CHO (trifluoroacetate salt)

Ac-DEVD-CHO (trifluoroacetate salt)

CAT N°: 10017
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From 68.00 57.80

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).{7777,7213} Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).{7777} Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Item No. 14465), are irreversible.{7777} Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.{10070}

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