A2764 (hydrochloride)

A2764 (hydrochloride)

CAT N°: 36943
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From 45.00 38.25

A2764 is an inhibitor of the two-pore domain potassium channel K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor).{65336} It is selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM. A2764 (100 µM) inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons.

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