A-<wbr/>967079

A-967079

CAT N°: 15207
Price:

From 97.00 82.45

The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation.{24761,24757} A-967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.{24758} It attenuates cold allodynia following nerve injury without producing locomotor or cardiovascular side effects.{24758} A-967079 also suppresses neuronal activity in response to mechanical stimulation and diminishes postoperative pain due to mechanical stimuli.{24759,24757}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime
  • Correlated keywords
    • pains channels blockers ions channels inhibitors neurosciences inhibits inhibitions potent TRPA1 TRPAs transient receptors potential ankyrin 1 one As 967079 A967079 selective bioavailable nerves injury injuries pumps blockers cold allodynia neuronal activity postoperative
  • Product Overview:
    The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation.{24761,24757} A-967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.{24758} It attenuates cold allodynia following nerve injury without producing locomotor or cardiovascular side effects.{24758} A-967079 also suppresses neuronal activity in response to mechanical stimulation and diminishes postoperative pain due to mechanical stimuli.{24759,24757}

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