A-834735 Degradant

Territorial Availability: Available through Bertin Technologies only in France

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• Synonyms
  • 3,3,4-trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one
• Correlated keywords
  • cannabinoids agonists CB1 CB2 pains neurosciences analgesia GC-MS fragmentations mass spectrometry chromatography gas McLafferty GC/MS GC MS A834734 A-834,734 A 834,734 834734 834 734 CBs fragments ions indoles 3-tetramethylcyclopropylmethanone blood-brain blood brains barriers hyperalgesia 895155-57-4 receptors agonists neurosciences forensics sciences analgesics derived indole-derived substituents central peripheral rats thermals impurity neuropathic pains models impurities analysis rearrangements analytical references standards
• Product Overview:
  A-834735 (Item No. 11163) is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively, and EC50 values of 12 and 0.21 nM, respectively.{22084} A-834735 readily crosses the blood-brain barrier, dose-dependently reversing thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.{22084} A-834735 degradant is a common impurity observed during GC-MS analysis of samples containing A-834735. The opened ring of the degradant is presumed to be produced during heating of A-834735. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of A-834735. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.{21911}