A 83-<wbr/>01

A 83-01

CAT N°: 9001799
Price:

From 43.00 36.55

A 83-01 is an inhibitor of TGF-? type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively).{31358} It blocks the phosphorylation of SMAD2/3 and inhibits TGF-?-induced epithelial-to-mesenchymal transition.{31358} It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK.{31358} A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes.{31142,31158}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
  • Correlated keywords
    • reprogram pluripotency TGF-? type I receptor ALK5 ALK4 ALK7 A8301 A-8301 TGF? ALK-4 ALK-5 ALK-7 Smad2 Smad3 Smad-2 Smad-3 Smad-2/3 A83-01 TGF-b TGFb
  • Product Overview:
    A 83-01 is an inhibitor of TGF-? type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively).{31358} It blocks the phosphorylation of SMAD2/3 and inhibits TGF-?-induced epithelial-to-mesenchymal transition.{31358} It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK.{31358} A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes.{31142,31158}

We also advise you