A-<wbr/>771726

A-771726

CAT N°: 14404
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From 92.00 78.20

A-771726 is an active metabolite of the prodrug leflunomide (Item No. 14860) that inhibits dihydroorotate dehydrogenase (DHODH; IC50 = 0.23 µM).{60466} A-771726 inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) in TNF-?- or IL-1?-stimulated isolated human synoviocytes (IC50s = 7 and 3 ?M, respectively).{22722} It inhibits the proliferation of isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 25 and 100 µM.{60467} A-771726 (3 and 10 mg/kg) delays disease onset and decreases neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by complete Freund’s adjuvant (CFA) and M. tuberculosis.{60468} Formulations containing teriflunomide have been used in the treatment of multiple sclerosis.

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