A-54556A

A-54556A

CAT N°: 15305
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From 513.00 436.05

A-54556A is an acyldepsipeptide (ADEP) antibiotic that has been found in Streptomyces hawaiiensis.{24688} It is active against B. subtilis, S. pyogenes, and E. faecalis, as well as penicillin-resistant S. pneumoniae, vancomycin-resistant E. faecium, and methicillin-resistant S. aureus (MRSA; IC50s = 0.2, 0.4, 0.4, 1.6, 0.4, and 6.3 µg/ml, respectively). It binds to and activates caseinolytic protease P (ClpP), inducing degradation of ?-casein by the B. subtilis ClpP in an ATPase-independent manner when used at concentrations of 2.5 and 5 µg/ml.

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