€653.00 €555.05
TGF-?-activated kinase 1 (TAK1) is a member of the serine/threonine MAP3K family that has roles in immunity and inflammation.{61776,61777} It binds to TAK1-binding protein 1 (TAB1) at its N-terminal kinase domain and to TAB2 and TAB3 at its C-terminal domain.{61776} TAK1 is ubiquitously expressed and constitutively associated with its activating binding partner TAB1, whereas it only associates with TAB2 and TAB3 following stimulation by upstream factors such as IL-1?.{61778,61779,61780,61777} It is involved in innate and adaptive immunity and the inflammatory response.{61776,61777} A TAK1-TAB1 fusion protein induces the activation of JNK, p38 MAPK, and I?B kinase (IKK) and the production of IL-6 in cancer cells.{61780} Tak1 knockdown induces splenomegaly and increases serum levels of several interleukin cytokines in mice.{61781} Hyperactivation of TAK1-TAB complexes is associated with autoimmune diseases and tumorigenesis.{61777} Cayman’s TAK1-TAB1 Fusion (human, recombinant) protein can be used for enzyme activity assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 3 mM DTT, and 20% glycerol |
| Purity | ≥93% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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