(S)-<wbr/>(?)-<wbr/>Linoleyl-<wbr/>1'-<wbr/>Hydroxy-<wbr/>2'-<wbr/>Propylamide

(S)-(?)-Linoleyl-1′-Hydroxy-2′-Propylamide

CAT N°: 9001236
Price:

122.00 103.70

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10 and 25 ?M for CB1 and CB2, respectively).{7422} It also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 ?M) and is hydrolyzed by FAAH, and inhibits voltage-gated K+ channels.{7251,3922,13859} (S)-(?)-Linoleyl-1’-hydroxy-2’-propylamide is a homolog of LOEA, characterized by the addition of an (S)-?-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-1 methanandamide (Item No. 90072) results in a diminished affinity for the CB receptor but greatly improved metabolic stability to aminopeptidase hydrolysis.{1092} The physiological actions of this compound have not been evaluated.

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