€602.00 €511.70
I?B kinase ? (IKK?) is a catalytic subunit of the I?B kinase (IKK) complex, a key mediator of NF-?B activation.{57847} It is composed of an N-terminal kinase domain, which contains an activation loop with two serine residues, Ser 177 and Ser 181, that are subject to phosphorylation, a ubiquitin-like domain, a scaffold dimerization domain, and a C-terminal domain that binds the regulatory subunit IKK?, also known as NF-?B essential modifier (NEMO). IKK? is ubiquitously expressed and localizes in the cytoplasm to the IKK complex, which mediates NF-?B activation in response to numerous stimuli, including inflammatory cytokines and B- and T cell receptor engagement, as well as LPS and growth factors. Upon cellular stimulation, the TAK1-TAB complex phosphorylates and activates IKK?, which induces phosphorylation and degradation of the NF-?B inhibitory protein I?B, permitting NF-?B nuclear translocation and the transcription of numerous genes involved in inflammation, immunity, and cell survival and proliferation.{57848,57847} IKK? has roles in several pathological conditions, including cancer and inflammatory diseases, such as rheumatoid arthritis.{57847} IKBKB mutations have been found in patients with severe combined immunodeficiency (SCID).{57849} Cayman’s IKK? (human, recombinant) protein can be used for enzyme activity assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | Active recombinant human N-terminal GST-tagged IKK? expressed in insect cells |
| Purity | ≥80% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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