FMK

FMK

CAT N°: 9000887
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From 66.00 56.10

FMK is an inhibitor of p90 ribosomal S6 kinase 3? (RSK2; IC50 = 15 nM).{61212} It inhibits the C-terminal domain (CTD) kinase activity of RSK2 and inhibits EGF-induced phosphorylation of RSK2 Ser386 in serum-starved COS-7 cells (EC50 = ~200 nM). FMK (6 µM) reduces invasion, but not proliferation, of M4e, 212LN, and 37B human head and neck squamous cell carcinoma cells.{61213} It also inhibits FGFR3-induced growth of Ba/F3 cells in a concentration-dependent manner and induces apoptosis in OPM-1, LP-1, and KMS-18 human myeloma cells expressing the t(4;14) translocation mutation and FGFR3 when used at a concentration of 10 µM.{61214}

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TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
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