Oxanosine

Oxanosine

CAT N°: 33503
Price:

853.00 725.05

Oxanosine is an analog of guanosine (Item No. 27702) that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties.{57641,57640} It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively).{57641} It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.{57640}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-amino-3-?-D-ribofuranosyl-imidazo[4,5-d][1,3]oxazin-7(3H)-one
  • Correlated keywords
    • NSC359452 Streptomyces anti-bacterial viral cancer Shigella Proteus Escherichia HIV1 U 937 H 9 L-1210
  • Product Overview:
    Oxanosine is an analog of guanosine (Item No. 27702) that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties.{57641,57640} It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively).{57641} It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.{57640}

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