13,14-<wbr/>dihydro-<wbr/>16,16-<wbr/>difluoro Prostaglandin E<sub>1</sub>

13,14-dihydro-16,16-difluoro Prostaglandin E1

CAT N°: 9000405
Price:

72.00 61.20

Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-?-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM){960,4165} and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.{2126,4165} The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.{17623}

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