17-<wbr/>oxo-<wbr/>4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-<wbr/>Docosahexaenoic Acid

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

CAT N°: 9000346
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17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity.{16994,16993,18161} It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPAR? agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).{18161}

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