Prostaglandin A<sub>2</sub> methyl ester

Prostaglandin A2 methyl ester

CAT N°: 9000185
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Prostaglandin A2 (PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense. At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at G1 and G2/M by preventing activation of cyclin-dependent kinases.{2678} At similar concentrations, it stabilizes transcripts for the tumor suppressor SMAR1, downregulating cyclin D1 expression.{18712} PGA2 also induces apoptosis in HL-60 cells.{18713} Prostaglandin A2 methyl ester is a lipophilic analog of PGA2 which may be more amenable for certain formulations or applications. Its biological properties have not been evaluated.

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