Remdesivir (CRM)

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Reference Materials RMs and Certified Reference Materials CRMs are dispatched directly to the end-user in accordance with ISO requirements.

• Synonyms
  • N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
• Correlated keywords
  • 2266584-38-5 GS-441524 GS441524 GS5734 anti-viral MERSCoV SARSCoV corona-virus pro-drug CoV2
• Product Overview:
  Remdesivir (CRM) (Item No. 32511) is a certified reference material categorized as an antiviral.{45842,45860,52859,61140} Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524 (Item No. 30469).{45842,45860} Following intravenous dosing in the mouse, it is distributed to the lungs and liver, among other organs.{57364} Upon entry into cells, remdesivir is rapidly and completely metabolized into a nucleoside monophosphate form, which is further metabolized to an active nucleoside triphosphate that induces RNA chain termination and inhibits viral polymerases.{52859,57364} It reduces the production of severe acute respiratory coronavirus 2 (SARS-CoV-2) in vitro and reduces lung viral titers and lung hemorrhage, as well as improves pulmonary function, in mice infected with a chimeric SARS-CoV encoding the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).{61140} Formulations containing remdesivir have been used in the treatment of COVID-19. This product is intended for use in analytical research applications. This product is also available as a general research tool (Item No. 30354).