20-HETE-d<sub>6</sub>

20-HETE-d6

CAT N°: 390030
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From 274.00 232.90

20-HETE-d6 contains six deuterium atoms at the 16, 16′, 17, 17′, 18 and 18′ positions. It is intended for use as an internal standard for the quantification of 20-HETE (Item No. 90030) by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.{7827} In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.{9023} 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.{1119}

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