From €102.00 €86.70
17-phenyl trinor Prostaglandin F2? ethyl amide-d4 (17-phenyl trinor PGF2? ethyl amide-d4) is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2? ethyl amide (Item No. 16820) by GC- or LC-MS. 17-phenyl trinor PGF2? ethyl amide is sold under the Allergan trade name Bimatoprost and is an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2? ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.{9311} The free acid, 17-phenyl trinor PGF2?, is a potent FP receptor agonist.{2058,1374} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg, 25 µg, 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C25H33D4NO4 |
| Smiles | O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1 |
| Molecular weight | 419,6 |
| Custom code | 3822.19 |
| Formulation | A solution in methyl acetate |
| Purity | ≥99% deuterated forms (d1-d4) |
| UNSPSC code | 12352100 |
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