17-<wbr/>phenyl trinor Prostaglandin F<sub>2?</sub> ethyl amide-<wbr/>d<sub>4</sub>

17-phenyl trinor Prostaglandin F2? ethyl amide-d4

CAT N°: 316820
Price:

102.00 86.70

17-phenyl trinor Prostaglandin F2? ethyl amide-d4 (17-phenyl trinor PGF2? ethyl amide-d4) is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2? ethyl amide (Item No. 16820) by GC- or LC-MS. 17-phenyl trinor PGF2? ethyl amide is sold under the Allergan trade name Bimatoprost and is an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2? ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.{9311} The free acid, 17-phenyl trinor PGF2?, is a potent FP receptor agonist.{2058,1374} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

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