Oleoyl Ethanolamide

Oleoyl Ethanolamide

CAT N°: 90265
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43.00 36.55

Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.{5291} It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,{2874} but its biosynthesis is reduced in the intestine of rats following food deprivation.{9302} OEA is an endogenous, potent agonist for PPAR?, exhibiting an EC50 value of 120 nM in a transactivation assay.{11423} Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPAR? wild-type mice, but not in PPAR? knockout mice.{9302,11423} These data indicate that OEA regulates food intake by a PPAR?-mediated mechanism.

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