€615.00 €522.75
CD14 is a membrane glycoprotein, pattern recognition receptor, and co-receptor for several toll-like receptors (TLRs).{58330,58329} It is composed of a C-terminal glycosylphosphatidylinositol (GPI) anchor, several sequences associated with LPS binding, and an N-terminal hydrophobic pocket containing leucine-rich repeats. CD14 is highly expressed on myeloid lineage cells, such as monocytes, dendritic cells, microglia, and macrophages, and is commonly used as a marker of monocyte differentiation.{58330} It is also expressed, to a lesser extent, in non-immune cells, and a soluble form of CD14 (sCD14) can be secreted in a protease-dependent or -independent manner to confer LPS-responsiveness to cells not expressing CD14. CD14 binds LPS in a concentration- and LPS chemotype-dependent manner to induce or suppress TLR-mediated LPS responses.{58330,58332} It also binds to various pathogen-associated molecular patterns (PAMPs) and heat shock protein 70 (Hsp70) to induce innate immune responses and cytokine production, respectively. CD14 deficiency inhibits LPS-induced inflammation in mouse lung, intestine, and liver and is protective against LPS- or E. coli-induced lethal inflammation in mouse models of systemic septic shock. CD14 expression is upregulated in monocytes, adipocytes, and whole adipose tissue isolated from individuals with obesity and patients with diabetes mellitus.{58331} Cayman’s CD14 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human CD14 |
| Clone | RM415 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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