LY171883

LY171883

CAT N°: 70710
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LY171883 is a selective, potent, orally active antagonist of the leukotriene D4 receptor.{1741} Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.{1741} LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 µM) and various guinea pig tissues (IC50s range from 6.9-209 µM).{1741} At a concentration of 50-100 µM, LY171883 binds to the PPAR? nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.{1618,1425}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-ethanone
  • Correlated keywords
    • LTD4 receptors antagonists leukotrienes ly-171883 cysLT1
  • Product Overview:
    LY171883 is a selective, potent, orally active antagonist of the leukotriene D4 receptor.{1741} Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.{1741} LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 µM) and various guinea pig tissues (IC50s range from 6.9-209 µM).{1741} At a concentration of 50-100 µM, LY171883 binds to the PPAR? nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.{1618,1425}

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